Battle Mania Daiginjou is a comical anime-themed scrolling shooter, and the sequel to Trouble Shooter. The player controls the Dirty Pair-esque Mania and Maria simultaneously, with Maria following closely behind Mania, and also able to turn around and fire to the rear. Unlike most shooters, Mania has a health meter which can be replenished via pickups. There are a variety of weapons to choose from at the start of each stage, and during the game, weapons can be powered up. There is also a screen-clearing bomb attack, but it must be allowed to charge back up each time it is used.

The game includes a standard single-player mode with three difficulty settings. There is also a score attack mode which challenges the player to earn the most points possible in two minutes on a set stage.